Large Cell Carcinoma Cells
Large cell carcinoma is a subtype of non-small cell lung cancer. It is responsible for about 15% of lung cancers making it among the rarest (though still common in terms of numbers of all cancers). Large cell carcinoma is identified as being different from the other types of lung cancers histologically. These cells do not have the necessary equipment to secrete substances like adenocarcinoma. Nor do they look like scales with keratin pearls, which would indicate squamous cell carcinoma. Large cell carcinoma appears rather strange under a microscope in that it looks like sheets of abnormal cells with an area of dead cells in the middle.
Large cell lung cancers do not necessarily occur near the chest wall, though they often occur near the edge of the lung rather than near a bronchus (in the center). Therefore, a needle biopsy may or may not be possible, depending on location. If a needle biopsy is not possible, a tissue sample may need to be gathered using a surgical approach. When this is needed, the entire tumor may be removed both for purposes of diagnosis and treatment.
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